› 6a4l

X-ray diffraction
2.8Å resolution

AcrR from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb6a4l/pdb
PDB entry 6a4l coloured by chain, front view.
PDB entry 6a4l coloured by chain, side view.
PDB entry 6a4l coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
The crystal structure of AcrR from Mycobacterium tuberculosis reveals a one-component transcriptional regulation mechanism.
Kang SM, Kim DH, Jin C, Ahn HC, Lee BJ
OpenAccess logo FEBS Open Bio 9 1713-1725 (2019)
PMID: 31369208

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-517592 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 230 amino acids
Theoretical weight: 25.93 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: O07229 (Residues: 1-210; Coverage: 100%)
Gene name: Rv0302
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand NA 3 x NA
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 5C (4A)
Spacegroup: P61
Unit cell:
a: 118.752Å b: 118.752Å c: 93.456Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.213 0.258
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Carbon Monoxide-Sensing Transcription Factors: Regulators of Microbial Carbon Monoxide Oxidation Pathway Gene Expression.
Dent et al. (2023)
6 other articles

1 mention without citation

The crystal structure of AcrR from Mycobacterium tuberculosis reveals a one-component transcriptional regulation mechanism.
Kang et al. (2019)