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VioC L-arginine hydroxylase bound to Fe(II), L-arginine, and a peroxysuccinate intermediate

Source organism: Streptomyces vinaceus
Biochemical function: 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity
Biological process: antibiotic biosynthetic process
Cellular component: membrane

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EC 1.14.11.41: L-arginine hydroxylase

Reaction catalysed:
L-arginine + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-arginine + succinate + CO(2)
Systematic name:
L-arginine,2-oxoglutarate:O(2) oxidoreductase (3-hydroxylating)
Alternative Name(s):
  • VioC

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02668
Domain description: Taurine catabolism dioxygenase TauD, TfdA family
Occurring in:
  1. Alpha-ketoglutarate-dependent L-arginine hydroxylase
The deposited structure of PDB entry 6alo contains 1 copy of Pfam domain PF02668 (Taurine catabolism dioxygenase TauD, TfdA family) in Alpha-ketoglutarate-dependent L-arginine hydroxylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003819
Domain description: TauD/TfdA-like domain
Occurring in:
  1. Alpha-ketoglutarate-dependent L-arginine hydroxylase
IPR023966
Domain description: Arginine beta-hydroxylase, Fe2/alpha-ketoglutarate-dependent
Occurring in:
  1. Alpha-ketoglutarate-dependent L-arginine hydroxylase
IPR042098
Domain description: Taurine dioxygenase TauD-like superfamily
Occurring in:
  1. Alpha-ketoglutarate-dependent L-arginine hydroxylase
IPR014503
Domain description: Clavaminate synthase-like
Occurring in:
  1. Alpha-ketoglutarate-dependent L-arginine hydroxylase

Structure domain

CATH CATH domain
3.60.130.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Double-stranded beta-helix
Homology: Clavaminate synthase-like
Occurring in:
  1. Alpha-ketoglutarate-dependent L-arginine hydroxylase
The deposited structure of PDB entry 6alo contains 1 copy of CATH domain 3.60.130.10 (Double-stranded beta-helix) in Alpha-ketoglutarate-dependent L-arginine hydroxylase. Showing 1 copy in chain A.

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