› 6amr

Solution NMR

Solution NMR structure of a putative thioredoxin (ECH_0218) in the reduced state from Ehrlichia chaffeensis, the etiological agent responsible for human monocytic ehrlichiosis. Seattle Structural Genomics Center for Infectious Disease target EhchA.00546.a

Released:
DOI: 10.2210/pdb6amr/pdb
PDB entry 6amr coloured by chain, ensemble of 20 models, front view.
PDB entry 6amr coloured by chain, ensemble of 20 models, side view.
PDB entry 6amr coloured by chain, ensemble of 20 models, top view.
Source organism: Ehrlichia chaffeensis str. Arkansas
Primary publication:
Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics.
Buchko GW, Hewitt SN, Van Voorhis WC, Myler PJ
Acta Crystallogr F Struct Biol Commun 74 46-56 (2018)
PMID: 29372907

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173598 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.36 KDa
Source organism: Ehrlichia chaffeensis str. Arkansas
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2GHP2 (Residues: 1-107; Coverage: 100%)
Gene names: ECH_0218, trx
Sequence domains: Thioredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The Thioredoxin System of Mammalian Cells and Its Modulators.
Hasan et al. (2022)
1 other article

1 mention without citation

Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics.
Buchko et al. (2018)