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E. coli phosphoenolpyruvate carboxykinase G209N mutant bound to thiosulfate

Source organism: Escherichia coli K-12
Biochemical function: metal ion binding
Biological process: gluconeogenesis
Cellular component: cytosol

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EC 4.1.1.49: Phosphoenolpyruvate carboxykinase (ATP)

Reaction catalysed:
ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2)
Systematic name:
ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)
Alternative Name(s):
  • ATP:oxaloacetate carboxy-lyase (transphosphorylating)
  • PEP carboxykinase
  • PEP carboxylase
  • PEPCK
  • PEPCK (ATP)
  • PEPK
  • Phosphoenolpyruvate carboxykinase
  • Phosphoenolpyruvate carboxylase
  • Phosphoenolpyruvate carboxylase (ATP)
  • Phosphoenolpyruvic carboxykinase
  • Phosphoenolpyruvic carboxylase
  • Phosphopyruvate carboxykinase
  • Phosphopyruvate carboxykinase (adenosine triphosphate)
  • Phosphopyruvate carboxylase
  • Phosphopyruvate carboxylase (ATP)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01293
Domain description: Phosphoenolpyruvate carboxykinase
Occurring in:
  1. Phosphoenolpyruvate carboxykinase (ATP)
The deposited structure of PDB entry 6at2 contains 1 copy of Pfam domain PF01293 (Phosphoenolpyruvate carboxykinase) in Phosphoenolpyruvate carboxykinase (ATP). Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001272
Domain description: Phosphoenolpyruvate carboxykinase, ATP-utilising
Occurring in:
  1. Phosphoenolpyruvate carboxykinase (ATP)
IPR008210
Domain description: Phosphoenolpyruvate carboxykinase, N-terminal
Occurring in:
  1. Phosphoenolpyruvate carboxykinase (ATP)
IPR015994
Domain description: Phosphoenolpyruvate carboxykinase (ATP), conserved site
Occurring in:
  1. Phosphoenolpyruvate carboxykinase (ATP)
IPR013035
Domain description: Phosphoenolpyruvate carboxykinase, C-terminal
Occurring in:
  1. Phosphoenolpyruvate carboxykinase (ATP)

Structure domains

CATH CATH domains
3.90.228.20
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Phosphoenolpyruvate Carboxykinase; domain 3
Homology: Phosphoenolpyruvate Carboxykinase; domain 3
Occurring in:
  1. Phosphoenolpyruvate carboxykinase (ATP)
The deposited structure of PDB entry 6at2 contains 1 copy of CATH domain 3.90.228.20 (Phosphoenolpyruvate Carboxykinase; domain 3) in Phosphoenolpyruvate carboxykinase (ATP). Showing 1 copy in chain A.
2.170.8.10
Class: Mainly Beta
Architecture: Beta Complex
Topology: Phosphoenolpyruvate Carboxykinase; domain 2
Homology: Phosphoenolpyruvate Carboxykinase, domain 2
Occurring in:
  1. Phosphoenolpyruvate carboxykinase (ATP)
The deposited structure of PDB entry 6at2 contains 1 copy of CATH domain 2.170.8.10 (Phosphoenolpyruvate Carboxykinase; domain 2) in Phosphoenolpyruvate carboxykinase (ATP). Showing 1 copy in chain A.
3.40.449.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Phosphoenolpyruvate Carboxykinase; domain 1
Homology: Phosphoenolpyruvate Carboxykinase, domain 1
Occurring in:
  1. Phosphoenolpyruvate carboxykinase (ATP)
The deposited structure of PDB entry 6at2 contains 1 copy of CATH domain 3.40.449.10 (Phosphoenolpyruvate Carboxykinase; domain 1) in Phosphoenolpyruvate carboxykinase (ATP). Showing 1 copy in chain A.

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