› 6ats

X-ray diffraction
1.9Å resolution

Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox

Released:
DOI: 10.2210/pdb6ats/pdb
PDB entry 6ats coloured by chain, front view.
PDB entry 6ats coloured by chain, side view.
PDB entry 6ats coloured by chain, top view.
Source organism: Chersonesometrus fulvipes
Primary publication:
Screening, large-scale production and structure-based classification of cystine-dense peptides.
Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK
OpenAccess logo Nat Struct Mol Biol 25 270-278 (2018)
PMID: 29483648

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160645 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel toxin kappa-KTx 1.2 Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 2.87 KDa
Source organism: Chersonesometrus fulvipes
Expression system: Homo sapiens
UniProt:
  • Canonical: P82851 (Residues: 1-23; Coverage: 100%)
Sequence domains: Hefutoxin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 46.102Å b: 21.323Å c: 20.368Å
α: 90° β: 92.6° γ: 90°
R-values:
R R work R free
0.134 0.132 0.179
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Miniproteins as a Powerful Modality in Drug Development.
Crook et al. (2020)
3 more

1 mention without citation

Screening, large-scale production and structure-based classification of cystine-dense peptides.
Correnti et al. (2018)