› 6ave

Electron Microscopy
3.7Å resolution

Structure of an acid sensing ion channel in a resting state at high pH

Released:
DOI: 10.2210/pdb6ave/pdb
PDB entry 6ave coloured by chain, front view.
PDB entry 6ave coloured by chain, side view.
PDB entry 6ave coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Gating mechanisms of acid-sensing ion channels.
Yoder N, Yoshioka C, Gouaux E
Nature 555 397-401 (2018)
PMID: 29513651
Related structures: EMD-7009

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acid-sensing ion channel 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 527 amino acids
Theoretical weight: 60.08 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1XA76 (Residues: 1-527; Coverage: 100%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-7009
Expression system: Homo sapiens

Quick links

Citations

22 review citations

Unravelling the Interplay between Extracellular Acidosis and Immune Cells.
Erra Díaz et al. (2018)
21 more

13 mentions without citation

Ion channels as therapeutic antibody targets.
Hutchings et al. (2019)
12 more