› 6b3r

Electron Microscopy
3.8Å resolution

Structure of the mechanosensitive channel Piezo1

Released:
DOI: 10.2210/pdb6b3r/pdb
PDB entry 6b3r coloured by chain, front view.
PDB entry 6b3r coloured by chain, side view.
PDB entry 6b3r coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure-based membrane dome mechanism for Piezo mechanosensitivity.
Guo YR, MacKinnon R
OpenAccess logo Elife 6 (2017)
PMID: 29231809
Related structures: EMD-7042

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122834 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Piezo-type mechanosensitive ion channel component 1 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 2547 amino acids
Theoretical weight: 292.32 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: E2JF22 (Residues: 1-2547; Coverage: 100%)
Gene names: Fam38a, Piezo1
Sequence domains:
Piezo-type mechanosensitive ion channel component 1, unknown fragment Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 16 amino acids
Theoretical weight: 1.38 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-7042
Expression system: Homo sapiens

Quick links

Citations

49 review citations

Channelling the Force to Reprogram the Matrix: Mechanosensitive Ion Channels in Cardiac Fibroblasts.
Stewart et al. (2021)
48 more

26 mentions without citation

Recent advances in our understanding of the structure and function of more unusual cation channels.
Brown et al. (2019)
25 more