Function and Biology

Cryo-EM structure of Type I-F CRISPR crRNA-guided Csy surveillance complex with bound anti-CRISPR protein AcrF1

Source organisms:
Biochemical function: protein binding
Biological process: defense response to virus
Cellular component: not assigned

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF09615
Domain description: CRISPR-associated protein (Cas_Csy3)
Occurring in:
  1. CRISPR-associated protein Csy3
The deposited structure of PDB entry 6b46 contains 6 copies of Pfam domain PF09615 (CRISPR-associated protein (Cas_Csy3)) in CRISPR-associated protein Csy3. Showing 1 copy in chain D [auth F].

PF20829
Domain description: Anti-CRISPR protein Acr30-35/AcrF1
Occurring in:
  1. Anti-CRISPR protein AcrF1
The deposited structure of PDB entry 6b46 contains 2 copies of Pfam domain PF20829 (Anti-CRISPR protein Acr30-35/AcrF1) in Anti-CRISPR protein AcrF1. Showing 1 copy in chain G [auth I].

PF09618
Domain description: CRISPR-associated protein (Cas_Csy4)
Occurring in:
  1. CRISPR-associated endonuclease Cas6/Csy4
The deposited structure of PDB entry 6b46 contains 1 copy of Pfam domain PF09618 (CRISPR-associated protein (Cas_Csy4)) in CRISPR-associated endonuclease Cas6/Csy4. Showing 1 copy in chain I [auth L].

InterPro InterPro annotations
IPR013399
Domain description: Type I-F CRISPR-associated protein Csy3
Occurring in:
  1. CRISPR-associated protein Csy3
IPR013396
Domain description: CRISPR-associated endoribonuclease Cas6/Csy4, subtype I-F/YPEST
Occurring in:
  1. CRISPR-associated endonuclease Cas6/Csy4
IPR042564
Domain description: CRISPR-associated endoribonuclease Cas6/Csy4, subtype I-F/YPEST superfamily
Occurring in:
  1. CRISPR-associated endonuclease Cas6/Csy4

Structure domains

CATH CATH domains
3.30.67.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Viral Envelope Glycoprotein; domain 2
Homology: Viral Envelope Glycoprotein; domain 2
Occurring in:
  1. Anti-CRISPR protein AcrF1
The deposited structure of PDB entry 6b46 contains 2 copies of CATH domain 3.30.67.30 (Viral Envelope Glycoprotein; domain 2) in Anti-CRISPR protein AcrF1. Showing 1 copy in chain G [auth I].
3.30.70.2540
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: CRISPR-associated endoribonuclease Cas6/Csy4
Occurring in:
  1. CRISPR-associated endonuclease Cas6/Csy4
The deposited structure of PDB entry 6b46 contains 1 copy of CATH domain 3.30.70.2540 (Alpha-Beta Plaits) in CRISPR-associated endonuclease Cas6/Csy4. Showing 1 copy in chain I [auth L].