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ALDH1A2 liganded with NAD and 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide (compound CM121)

X-ray diffraction
2.3Å resolution
PDB entry 6b5h coloured by chain, front view.
PDB entry 6b5h coloured by chain, side view.
PDB entry 6b5h coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Retinal dehydrogenase 2
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Multimeric state: homo tetramer
Accessible surface area: 58286.88 Å2
Buried surface area: 24654.55 Å2
Dissociation area: 4,743.49 Å2
Dissociation energy (ΔGdiss): 32.23 kcal/mol
Dissociation entropy (TΔSdiss): 16.71 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-131758

Macromolecules

Retinal dehydrogenase 2
Chains: A, B, C, D
Length: 493 amino acids
Theoretical weight: 54.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94788 (Residues: 26-518; Coverage: 95%)
Gene names: ALDH1A2, RALDH2
Pfam: Aldehyde dehydrogenase family
InterPro:
Retinal dehydrogenase 2 in PDB entry 6b5h, assembly 1, front view.
Retinal dehydrogenase 2 in PDB entry 6b5h, assembly 1, side view.
Retinal dehydrogenase 2 in PDB entry 6b5h, assembly 1, top view.
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