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Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and Adenosine

Source organism: Cryptosporidium parvum Iowa II
Biochemical function: ATP binding
Biological process: lysyl-tRNA aminoacylation
Cellular component: membrane

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EC 6.1.1.6: Lysine--tRNA ligase

Reaction catalysed:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
Systematic name:
L-lysine:tRNA(Lys) ligase (AMP-forming)
Alternative Name(s):
  • L-lysine-transfer RNA ligase
  • Lysine translase
  • Lysine-tRNA synthetase
  • Lysyl-tRNA synthetase
  • Lysyl-transfer RNA synthetase
  • Lysyl-transfer ribonucleate synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00152
Domain description: tRNA synthetases class II (D, K and N)
Occurring in:
  1. Lysine--tRNA ligase

PF01336
Domain description: OB-fold nucleic acid binding domain
Occurring in:
  1. Lysine--tRNA ligase

InterPro InterPro annotations
IPR018149
Domain description: Lysyl-tRNA synthetase, class II, C-terminal
Occurring in:
  1. Lysine--tRNA ligase
IPR045864
Domain description: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Occurring in:
  1. Lysine--tRNA ligase
IPR002313
Domain description: Lysine-tRNA ligase, class II
Occurring in:
  1. Lysine--tRNA ligase
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. Lysine--tRNA ligase
IPR006195
Domain description: Aminoacyl-tRNA synthetase, class II
Occurring in:
  1. Lysine--tRNA ligase
IPR004364
Domain description: Aminoacyl-tRNA synthetase, class II (D/K/N)
Occurring in:
  1. Lysine--tRNA ligase
IPR004365
Domain description: OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
Occurring in:
  1. Lysine--tRNA ligase
IPR044136
Domain description: Lysine-tRNA ligase, class II, N-terminal
Occurring in:
  1. Lysine--tRNA ligase
IPR034762
Domain description: Bacterial/eukaryotic lysine-tRNA ligase, class II
Occurring in:
  1. Lysine--tRNA ligase

Structure domains

CATH CATH domains
3.30.930.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: BirA Bifunctional Protein; domain 2
Homology: Bira Bifunctional Protein; Domain 2
Occurring in:
  1. Lysine--tRNA ligase
2.40.50.140
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: Nucleic acid-binding proteins
Occurring in:
  1. Lysine--tRNA ligase

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