EC 3.1.11.2: Exodeoxyribonuclease III
Reaction catalysed:
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
Systematic name:
-
Alternative Name(s):
- E. coli exonuclease III
- E.coli exonuclease III
- Endoribonuclease III
- Escherichia coli exonuclease III
- Exonuclease III
GO terms
Biochemical function:
- DNA-(abasic site) binding
- phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
- class II DNA-(apurinic or apyrimidinic site) endonuclease activity
- metal ion binding
- chromatin DNA binding
- site-specific endodeoxyribonuclease activity, specific for altered base
- oxidoreductase activity
- 3'-5' exonuclease activity
- double-stranded DNA 3'-5' DNA exonuclease activity
- double-stranded DNA exodeoxyribonuclease activity
- 3'-5'-DNA exonuclease activity
- phosphoric diester hydrolase activity
- protein binding
- uracil DNA N-glycosylase activity
- phosphodiesterase I activity
- exonuclease activity
- RNA-DNA hybrid ribonuclease activity
- DNA endonuclease activity
- endonuclease activity
- nuclease activity
- DNA-(apurinic or apyrimidinic site) endonuclease activity
- catalytic activity
- RNA binding
- transcription corepressor activity
- transcription coactivator activity
- double-stranded telomeric DNA binding
- damaged DNA binding
- DNA binding
Biological process:
- telomere maintenance via base-excision repair
- positive regulation of transcription by RNA polymerase II
- negative regulation of DNA-templated transcription
- cell redox homeostasis
- positive regulation of gene expression via chromosomal CpG island demethylation
- regulation of mRNA stability
- regulation of apoptotic process
- DNA recombination
- DNA catabolic process
- base-excision repair, gap-filling
- base-excision repair
- DNA repair
- telomere maintenance
Protein family (Pfam)
InterPro annotations
CATH domain