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E. coli MsbA in complex with LPS and inhibitor G092

Source organism: Escherichia coli CFT073
Biochemical function: ABC-type transporter activity
Biological process: transmembrane transport
Cellular component: membrane

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EC 7.5.2.6: ABC-type lipid A-core oligosaccharide transporter

Reaction catalysed:
ATP + H(2)O + lipid A-core oligosaccharide(Side 1) = ADP + phosphate + lipid A-core oligosaccharide(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, lipid A-core oligosaccharide-translocating)
Alternative Name(s):
  • ATP-dependent lipid A-core flippase
  • Lipid flippase
  • MsbA

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. ATP-dependent lipid A-core flippase
The deposited structure of PDB entry 6bpp contains 2 copies of Pfam domain PF00005 (ABC transporter) in ATP-dependent lipid A-core flippase. Showing 1 copy in chain A.

PF00664
Domain description: ABC transporter transmembrane region
Occurring in:
  1. ATP-dependent lipid A-core flippase
The deposited structure of PDB entry 6bpp contains 2 copies of Pfam domain PF00664 (ABC transporter transmembrane region) in ATP-dependent lipid A-core flippase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. ATP-dependent lipid A-core flippase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. ATP-dependent lipid A-core flippase
IPR011527
Domain description: ABC transporter type 1, transmembrane domain
Occurring in:
  1. ATP-dependent lipid A-core flippase
IPR036640
Domain description: ABC transporter type 1, transmembrane domain superfamily
Occurring in:
  1. ATP-dependent lipid A-core flippase
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. ATP-dependent lipid A-core flippase
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. ATP-dependent lipid A-core flippase
IPR011917
Domain description: ABC transporter, lipid A-core flippase, MsbA
Occurring in:
  1. ATP-dependent lipid A-core flippase
IPR039421
Domain description: Type 1 protein exporter
Occurring in:
  1. ATP-dependent lipid A-core flippase

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