› 6bwf

Electron Microscopy
4.1Å resolution

4.1 angstrom Mg2+-unbound structure of mouse TRPM7

Released:
DOI: 10.2210/pdb6bwf/pdb
PDB entry 6bwf coloured by chain, front view.
PDB entry 6bwf coloured by chain, side view.
PDB entry 6bwf coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.
Duan J, Li Z, Li J, Hulse RE, Santa-Cruz A, Valinsky WC, Abiria SA, Krapivinsky G, Zhang J, Clapham DE
Proc Natl Acad Sci U S A 115 E8201-E8210 (2018)
PMID: 30108148
Related structures: EMD-7298

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 954 amino acids
Theoretical weight: 107.48 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q923J1 (Residues: 467-1300; Coverage: 45%)
Gene names: Chak, Ltrpc7, Trpm7
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-7298
Expression system: Spodoptera frugiperda

Quick links

Citations

21 review citations

TRPM7, Magnesium, and Signaling.
Zou et al. (2019)
20 more

5 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
4 more