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Crystal structure of LpxC from Pseudomonas aeruginosa in complex with racemic ligand PT803

Source organism: Pseudomonas aeruginosa UCBPP-PA14
Biochemical function: UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological process: carbohydrate derivative metabolic process
Cellular component: membrane

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EC 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase

Reaction catalysed:
UDP-3-O-((3R)-3-hydroxyacyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxyacyl)-alpha-D-glucosamine + acetate
Systematic name:
UDP-3-O-((3R)-3-hydroxymyristoyl)-N-acetyl-alpha-D-glucosamine amidohydrolase
Alternative Name(s):
  • Deacetylase LpxC
  • LpxC
  • LpxC deacetylase
  • LpxC enzyme
  • UDP-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase
  • UDP-(3-O-acyl)-N-acetylglucosamine deacetylase
  • UDP-3-O-((3R)-3-hydroxymyristoyl)-N-acetylglucosamine amidohydrolase
  • UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
  • UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase
  • UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase
  • UDP-3-O-acyl-GlcNAc deacetylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03331
Domain description: UDP-3-O-acyl N-acetylglycosamine deacetylase
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
The deposited structure of PDB entry 6c9c contains 1 copy of Pfam domain PF03331 (UDP-3-O-acyl N-acetylglycosamine deacetylase) in UDP-3-O-acyl-N-acetylglucosamine deacetylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004463
Domain description: UDP-3-O-acyl N-acetylglucosamine deacetylase
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
IPR020568
Domain description: Ribosomal protein uS5 domain 2-type superfamily
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
IPR011334
Domain description: UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
IPR015870
Domain description: UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase

Structure domains

CATH CATH domains
3.30.1700.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: lpxc deacetylase, domain 1
Homology: lpxc deacetylase, domain 2
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
The deposited structure of PDB entry 6c9c contains 1 copy of CATH domain 3.30.1700.10 (lpxc deacetylase, domain 1) in UDP-3-O-acyl-N-acetylglucosamine deacetylase. Showing 1 copy in chain A.
3.30.230.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Ribosomal Protein S5; domain 2
Homology: lpxc deacetylase, domain 1
Occurring in:
  1. UDP-3-O-acyl-N-acetylglucosamine deacetylase
The deposited structure of PDB entry 6c9c contains 1 copy of CATH domain 3.30.230.20 (Ribosomal Protein S5; domain 2) in UDP-3-O-acyl-N-acetylglucosamine deacetylase. Showing 1 copy in chain A.

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