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x-ray structure of NeoB from streptomyces fradiae in complex with PLP and neomycin (as the external aldimine) at pH 9

Source organism: Streptomyces fradiae
Biochemical function: pyridoxal phosphate binding
Biological process: neomycin biosynthetic process
Cellular component: not assigned

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EC 2.6.1.95: Neomycin C transaminase

Reaction catalysed:
Neomycin C + 2-oxoglutarate = 6'''-deamino-6'''-oxoneomycin C + L-glutamate
Systematic name:
2-oxoglutarate:neomycin C aminotransferase
Alternative Name(s):
  • NeoN (gene name)

EC 2.6.1.93: Neamine transaminase

Reaction catalysed:
Neamine + 2-oxoglutarate = 6'-dehydroparomamine + L-glutamate
Systematic name:
Neamine:2-oxoglutarate aminotransferase
Alternative Name(s):
  • BtrB (gene name)
  • Glutamate--6'-dehydroparomamine aminotransferase
  • KacL (gene name)
  • NeoN (gene name)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00202
Domain description: Aminotransferase class-III
Occurring in:
  1. Neamine transaminase NeoN
The deposited structure of PDB entry 6cbm contains 4 copies of Pfam domain PF00202 (Aminotransferase class-III) in Neamine transaminase NeoN. Showing 2 copies in chain A.

InterPro InterPro annotations
IPR005814
Domain description: Aminotransferase class-III
Occurring in:
  1. Neamine transaminase NeoN
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Neamine transaminase NeoN
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Neamine transaminase NeoN
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Neamine transaminase NeoN

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