› 6cfh

Electron crystallography
1.5Å resolution

SWGMMGMLASQ segment from the low complexity domain of TDP-43

Released:
DOI: 10.2210/pdb6cfh/pdb
PDB entry 6cfh coloured by chain, front view.
PDB entry 6cfh coloured by chain, side view.
PDB entry 6cfh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS
Nat Struct Mol Biol 25 463-471 (2018)
PMID: 29786080
Related structures: EMD-7467

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo icosamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171564 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chains: A, B
Molecule details ›
Chains: A, B
Length: 11 amino acids
Theoretical weight: 1.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13148 (Residues: 333-343; Coverage: 3%)
Gene names: TARDBP, TDP43

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 1.5Å
Relevant EMDB volumes: EMD-7467
Expression system: Not provided

Quick links

Citations

32 review citations

The molecular language of membraneless organelles.
Gomes et al. (2019)
31 more

4 mentions without citation

Structural Insights Into TDP-43 and Effects of Post-translational Modifications.
François-Moutal et al. (2019)
3 more