› 6cgb

X-ray diffraction
2.99Å resolution

chimera of mouse cadherin-11 EC1 and mouse cadherin-6 EC2

Released:
DOI: 10.2210/pdb6cgb/pdb
PDB entry 6cgb coloured by chain, front view.
PDB entry 6cgb coloured by chain, side view.
PDB entry 6cgb coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior.
Brasch J, Katsamba PS, Harrison OJ, Ahlsén G, Troyanovsky RB, Indra I, Kaczynska A, Kaeser B, Troyanovsky S, Honig B, Shapiro L
OpenAccess logo Cell Rep 23 1840-1852 (2018)
PMID: 29742438

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157292 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-11; Cadherin-6 Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 22.78 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P55288 (Residues: 54-155; Coverage: 13%)
  • Canonical: P97326 (Residues: 156-260; Coverage: 14%)
Gene names: Cad-11, Cdh11, Cdh6
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

3 bound ligands:
Ligand CA 3 x CA
Ligand ACT 1 x ACT
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: I212121
Unit cell:
a: 53.496Å b: 81.03Å c: 166.192Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.272 0.27 0.3
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.
Honig et al. (2020)
4 more

1 mention without citation

Homophilic and Heterophilic Interactions of Type II Cadherins Identify Specificity Groups Underlying Cell-Adhesive Behavior.
Brasch et al. (2018)