› 6chb

X-ray diffraction
6.8Å resolution

Crystal structure of a natively-glycosylated BG505 SOSIP.664 HIV-1 Envelope Trimer in complex with the broadly-neutralizing antibodies BG18 and IOMA

Released:
DOI: 10.2210/pdb6chb/pdb
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PDB entry 6chb coloured by chain, front view.
PDB entry 6chb coloured by chain, side view.
PDB entry 6chb coloured by chain, top view.
Source organisms:
Primary publication:
Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.
Barnes CO, Gristick HB, Freund NT, Escolano A, Lyubimov AY, Hartweger H, West AP, Cohen AE, Nussenzweig MC, Bjorkman PJ
OpenAccess logo Nat Commun 9 1251 (2018)
PMID: 29593217

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-231372 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 153 amino acids
Theoretical weight: 17.16 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q2N0S5 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
Envelope glycoprotein gp160 Chains: F, G, H
Molecule details ›
Chains: F, G, H
Length: 479 amino acids
Theoretical weight: 53.69 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q2N0S6 (Residues: 30-508; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
BG18 Heavy Chain Chains: I, J, Q
BG18 Light Chain Chains: K, L, R
IOMA Heavy Chain Chains: D, M, O
IOMA Light Chain Chains: E, N, P

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P43212
Unit cell:
a: 176.752Å b: 176.752Å c: 458.039Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.323 0.318 0.417
Expression systems:
  • Cricetulus griseus
  • Homo sapiens

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Citations

19 review citations

Recent progress in broadly neutralizing antibodies to HIV.
Sok et al. (2018)
18 more

2 mentions without citation

Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope.
Barnes et al. (2018)
1 more

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