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Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG071

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00439
Domain description: Bromodomain
Occurring in:
  1. Bromodomain-containing protein 4
The deposited structure of PDB entry 6cj1 contains 1 copy of Pfam domain PF00439 (Bromodomain) in Bromodomain-containing protein 4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001487
Domain description: Bromodomain
Occurring in:
  1. Bromodomain-containing protein 4
IPR036427
Domain description: Bromodomain-like superfamily
Occurring in:
  1. Bromodomain-containing protein 4
IPR018359
Domain description: Bromodomain, conserved site
Occurring in:
  1. Bromodomain-containing protein 4
IPR043508
Domain description: Brdt, bromodomain, repeat I
Occurring in:
  1. Bromodomain-containing protein 4

Structure domain

CATH CATH domain
1.20.920.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Histone Acetyltransferase; Chain A
Homology: Bromodomain-like
Occurring in:
  1. Bromodomain-containing protein 4
The deposited structure of PDB entry 6cj1 contains 1 copy of CATH domain 1.20.920.10 (Histone Acetyltransferase; Chain A) in Bromodomain-containing protein 4. Showing 1 copy in chain A.

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