› 6cl3

Solution NMR

LyeTxI-b, a synthetic peptide derived from Lycosa erythrognatha spider venom, shows potent antibiotic activity, in vitro and in vivo

Released:
DOI: 10.2210/pdb6cl3/pdb
PDB entry 6cl3 coloured by chain, ensemble of 10 models, front view.
PDB entry 6cl3 coloured by chain, ensemble of 10 models, side view.
PDB entry 6cl3 coloured by chain, ensemble of 10 models, top view.
Source organism: Lycosa erythrognatha
Primary publication:
LyeTxI-b, a Synthetic Peptide Derived From Lycosa erythrognatha Spider Venom, Shows Potent Antibiotic Activity in Vitro and in Vivo.
Reis PVM, Boff D, Verly RM, Melo-Braga MN, Cortés ME, Santos DM, Pimenta AMC, Amaral FA, Resende JM, de Lima ME
OpenAccess logo Front Microbiol 9 667 (2018)
PMID: 29681894

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110951 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toxin LyeTx 1 Chain: A
Molecule details ›
Chain: A
Length: 26 amino acids
Theoretical weight: 2.73 KDa
Source organism: Lycosa erythrognatha
Expression system: Not provided
UniProt:
  • Canonical: C0HJU9 (Residues: 1-25; Coverage: 96%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 77%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

6 review citations

Animal toxins - Nature's evolutionary-refined toolkit for basic research and drug discovery.
Herzig et al. (2020)
5 more

4 mentions without citation

Antimicrobials from Venomous Animals: An Overview.
Yacoub et al. (2020)
3 more