› 6co7

Electron Microscopy
3.07Å resolution

Structure of the nvTRPM2 channel in complex with Ca2+

Released:
DOI: 10.2210/pdb6co7/pdb
PDB entry 6co7 coloured by chain, front view.
PDB entry 6co7 coloured by chain, side view.
PDB entry 6co7 coloured by chain, top view.
Source organism: Nematostella vectensis
Primary publication:
Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.
Zhang Z, Tóth B, Szollosi A, Chen J, Csanády L
OpenAccess logo Elife 7 (2018)
PMID: 29745897
Related structures: EMD-7542

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-501228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Transient receptor potential cation channel subfamily M member-like 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1560 amino acids
Theoretical weight: 176.66 KDa
Source organism: Nematostella vectensis
Expression system: Homo sapiens
UniProt:
  • Canonical: A7T1N0 (Residues: 1-1551; Coverage: 100%)
Gene names: TRPM2, v1g248535
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand CLR 4 x CLR
Ligand POV 56 x POV
Ligand CA 4 x CA
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.07Å
Relevant EMDB volumes: EMD-7542
Expression system: Homo sapiens

Quick links

Citations

35 review citations

TRPM2 in Cancer.
Miller BA. (2019)
34 more

21 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
20 more