› 6cyf

X-ray diffraction
2.78Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-230691 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Type III secretion system protein Chains: A, B, I, Q
Molecule details ›
Chains: A, B, I, Q
Length: 128 amino acids
Theoretical weight: 14.03 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli
UniProt:
  • Canonical: M4Q7H6 (Residues: 132-248; Coverage: 40%)
Gene name: pcrV
Sequence domains: V antigen (LcrV) protein
IgG1 antibody, kappa light chain Chains: C, E, L, T
Molecule details ›
Chains: C, E, L, T
Length: 214 amino acids
Theoretical weight: 23.42 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
IgG1 antibody, heavy chain fragment Chains: D, F, M, U
Molecule details ›
Chains: D, F, M, U
Length: 227 amino acids
Theoretical weight: 24.13 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: Cu FINE FOCUS
Spacegroup: P212121
Unit cell:
a: 80.686Å b: 160.384Å c: 260.681Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.215 0.249
Expression systems:
  • Escherichia coli
  • Cricetulus griseus

Quick links

Citations

15 review citations

Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Infections.
Horcajada et al. (2019)
14 more

4 mentions without citation

On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome.
Lyons et al. (2019)
3 more