› 6d1w

Electron Microscopy
3.54Å resolution

human PKD2 F604P mutant

Released:
DOI: 10.2210/pdb6d1w/pdb
PDB entry 6d1w coloured by chain, front view.
PDB entry 6d1w coloured by chain, side view.
PDB entry 6d1w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkley D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ
OpenAccess logo Nat Commun 9 2302 (2018)
PMID: 29899465
Related structures: EMD-7786

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171761 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycystin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 740 amino acids
Theoretical weight: 85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13563 (Residues: 53-792; Coverage: 76%)
Gene names: PKD2, TRPP2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.54Å
Relevant EMDB volumes: EMD-7786
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Hydrophobic dewetting in gating and regulation of transmembrane protein ion channels.
Yazdani et al. (2020)
8 more

4 mentions without citation

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.
Zheng et al. (2018)
3 more