› 6d2s

X-ray diffraction
1.82Å resolution

Mycobacterium tuberculosis transcriptional regulator

Released:
DOI: 10.2210/pdb6d2s/pdb
PDB entry 6d2s coloured by chain, front view.
PDB entry 6d2s coloured by chain, side view.
PDB entry 6d2s coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.
Tang S, Hicks ND, Cheng YS, Silva A, Fortune SM, Sacchettini JC
OpenAccess logo Nucleic Acids Res 47 9934-9949 (2019)
PMID: 31504787

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulator PrpR Chain: A
Molecule details ›
Chain: A
Length: 289 amino acids
Theoretical weight: 32.5 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O06581 (Residues: 155-440; Coverage: 59%)
Gene names: P425_01178, RVBD_1129c, Rv1129c, prpR
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand CA 2 x CA
Ligand CL 2 x CL
Ligand NA 2 x NA
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: I222
Unit cell:
a: 74.999Å b: 81.724Å c: 95.365Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.209
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Transcriptional regulation and drug resistance in Mycobacterium tuberculosis.
Miotto et al. (2022)
1 more

3 mentions without citation

Recent Advances in Protein Homology Detection Propelled by Inter-Residue Interaction Map Threading.
Bhattacharya et al. (2021)
2 more