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Thermostabilized phosphorylated chicken CFTR

Source organism: Gallus gallus
Biochemical function: ABC-type transporter activity
Biological process: chloride transmembrane transport
Cellular component: recycling endosome membrane

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EC 5.6.1.6: Channel-conductance-controlling ATPase

Reaction catalysed:
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel
Systematic name:
ATP phosphohydrolase (channel-conductance-controlling)
Alternative Name(s):
  • CFTR
  • Cystic-fibrosis membrane-conductance-regulating protein

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00005
Domain description: ABC transporter
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
The deposited structure of PDB entry 6d3s contains 2 copies of Pfam domain PF00005 (ABC transporter) in Cystic fibrosis transmembrane conductance regulator. Showing 2 copies in chain A.

PF00664
Domain description: ABC transporter transmembrane region
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
The deposited structure of PDB entry 6d3s contains 2 copies of Pfam domain PF00664 (ABC transporter transmembrane region) in Cystic fibrosis transmembrane conductance regulator. Showing 2 copies in chain A.

PF14396
Domain description: Cystic fibrosis TM conductance regulator (CFTR), regulator domain
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
The deposited structure of PDB entry 6d3s contains 1 copy of Pfam domain PF14396 (Cystic fibrosis TM conductance regulator (CFTR), regulator domain) in Cystic fibrosis transmembrane conductance regulator. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR009147
Domain description: Cystic fibrosis transmembrane conductance regulator
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR011527
Domain description: ABC transporter type 1, transmembrane domain
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR036640
Domain description: ABC transporter type 1, transmembrane domain superfamily
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR025837
Domain description: CFTR regulator domain
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Cystic fibrosis transmembrane conductance regulator

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