› 6d7x

X-ray diffraction
3.6Å resolution

Crystal Structure of Rat TRPV6*-Y466A- in complex with brominated 2-Aminoethoxydiphenyl borate (2-APB-Br)

Released:
DOI: 10.2210/pdb6d7x/pdb
PDB entry 6d7x coloured by chain, front view.
PDB entry 6d7x coloured by chain, side view.
PDB entry 6d7x coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB.
Singh AK, Saotome K, McGoldrick LL, Sobolevsky AI
OpenAccess logo Nat Commun 9 2465 (2018)
PMID: 29941865

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 6 Chain: A
Molecule details ›
Chain: A
Length: 672 amino acids
Theoretical weight: 77.04 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9R186 (Residues: 41-709; Coverage: 87%)
Gene name: Trpv6
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand CA 2 x CA
Ligand FYY 1 x FYY
Ligand DTB 1 x DTB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P4212
Unit cell:
a: 144.35Å b: 144.35Å c: 113.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.284 0.282 0.316
Expression system: Homo sapiens

Quick links

Citations

12 review citations

Transient Receptor Potential Channels and Calcium Signaling.
Vangeel et al. (2019)
11 more

5 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
4 more