› 6d81

X-ray diffraction
2.25Å resolution

Structure of the Bovine p85a BH domain

Released:
DOI: 10.2210/pdb6d81/pdb
PDB entry 6d81 coloured by chain, front view.
PDB entry 6d81 coloured by chain, side view.
PDB entry 6d81 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation.
Mellor P, Marshall JDS, Ruan X, Whitecross DE, Ross RL, Knowles MA, Moore SA, Anderson DH
OpenAccess logo Sci Rep 8 7108 (2018)
PMID: 29740032

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150051 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 193 amino acids
Theoretical weight: 21.91 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23727 (Residues: 110-302; Coverage: 27%)
Gene name: PIK3R1
Sequence domains: RhoGAP domain
Structure domains: Rho GTPase activation protein

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
1 modified residue:
Ligand CSO 2 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 85.825Å b: 91.737Å c: 93.778Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.213
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Conformationally active integrin endocytosis and traffic: why, where, when and how?
Mana et al. (2020)
1 more

4 mentions without citation

Impact of p85α Alterations in Cancer.
Marshall et al. (2019)
3 more