› 6dgp

X-ray diffraction
3.1Å resolution

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with TRAP220 Coactivator Peptide

Released:
DOI: 10.2210/pdb6dgp/pdb
Model geometry
Fit model/data
PDB entry 6dgp coloured by chain, front view.
PDB entry 6dgp coloured by chain, side view.
PDB entry 6dgp coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shang J, Kojetin DJ

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153372 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 297 amino acids
Theoretical weight: 34.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
TRAP220 Coactivator Peptide (Mediator of RNA polymerase II transcription subunit 1) Chains: C, D
Molecule details ›
Chains: C, D
Length: 19 amino acids
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 88.09Å b: 54.73Å c: 123.471Å
α: 90° β: 90.05° γ: 90°
R-values:
R R work R free
0.229 0.222 0.294
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli

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