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Crystal structure of HCV NS3/4A protease in complex with P4-3(AJ-74)

Source organism: Hepacivirus hominis
Biochemical function: metal ion binding
Biological process: symbiont entry into host cell
Cellular component: virion component

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EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02907
Domain description: Hepatitis C virus NS3 protease
Occurring in:
  1. Peptidase S29 domain-containing protein
The deposited structure of PDB entry 6diu contains 1 copy of Pfam domain PF02907 (Hepatitis C virus NS3 protease) in NS3 protease. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004109
Domain description: Hepatitis C virus, NS3 protease
Occurring in:
  1. Peptidase S29 domain-containing protein
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Peptidase S29 domain-containing protein
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Peptidase S29 domain-containing protein

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