› 6dld

X-ray diffraction
3.3Å resolution

Crystal structure of IgLON5/NEGR1 heterodimer

Released:
DOI: 10.2210/pdb6dld/pdb
PDB entry 6dld coloured by chain, front view.
PDB entry 6dld coloured by chain, side view.
PDB entry 6dld coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a heterodimer of neuronal cell surface proteins
Ranaivoson FM, Turk LS, Ozkan E, Montelione GT, Comoletti D
Structure (2019)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107993 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
IgLON family member 5 Chains: A, C
Molecule details ›
Chains: A, C
Length: 303 amino acids
Theoretical weight: 33.54 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: A6NGN9 (Residues: 31-316; Coverage: 94%)
Gene name: IGLON5
Sequence domains:
Neuronal growth regulator 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 304 amino acids
Theoretical weight: 33.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7Z3B1 (Residues: 38-324; Coverage: 91%)
Gene names: IGLON4, NEGR1, UNQ2433/PRO4993
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand NAG 15 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2
Unit cell:
a: 120.341Å b: 305.799Å c: 60.029Å
α: 90° β: 100.78° γ: 90°
R-values:
R R work R free
0.247 0.245 0.286
Expression system: Homo sapiens

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