› 6dmr

Electron Microscopy
3.9Å resolution

Lipid-bound full-length rbTRPV5

Released:
DOI: 10.2210/pdb6dmr/pdb
PDB entry 6dmr coloured by chain, front view.
PDB entry 6dmr coloured by chain, side view.
PDB entry 6dmr coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural insights on TRPV5 gating by endogenous modulators.
Hughes TET, Pumroy RA, Yazici AT, Kasimova MA, Fluck EC, Huynh KW, Samanta A, Molugu SK, Zhou ZH, Carnevale V, Rohacs T, Moiseenkova-Bell VY
OpenAccess logo Nat Commun 9 4198 (2018)
PMID: 30305626
Related structures: EMD-7965

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 730 amino acids
Theoretical weight: 82.9 KDa
Source organism: Oryctolagus cuniculus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9XSM3 (Residues: 1-730; Coverage: 100%)
Gene names: Ecac1, Trpv5
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-7965
Expression system: Saccharomyces cerevisiae

Quick links

Citations

23 review citations

Novel roles of phosphoinositides in signaling, lipid transport, and disease.
Hammond et al. (2020)
22 more

6 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
5 more