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Cryo EM structure of human SEIPIN

Electron Microscopy
3.8Å resolution
PDB entry 6ds5 coloured by chain, front view.
PDB entry 6ds5 coloured by chain, side view.
PDB entry 6ds5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo undecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Seipin
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Multimeric state: homo undecamer
Accessible surface area: 90147.16 Å2
Buried surface area: 30704.11 Å2
Dissociation area: 12,181.25 Å2
Dissociation energy (ΔGdiss): 49.94 kcal/mol
Dissociation entropy (TΔSdiss): 132.55 kcal/mol
Symmetry number: 11
PDBe Complex ID: PDB-CPX-188514

Macromolecules

Seipin
Chains: A, B, C, D, E, F, G, H, I, J, K
Length: 409 amino acids
Theoretical weight: 45.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96G97 (Residues: 2-398; Coverage: 100%)
Gene name: BSCL2
Pfam: Putative adipose-regulatory protein (Seipin)
InterPro: Seipin family
Seipin in PDB entry 6ds5, assembly 1, front view.
Seipin in PDB entry 6ds5, assembly 1, side view.
Seipin in PDB entry 6ds5, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q96G97  
140950100150200250300350400
 
100200300400MSGRWSHPQFEKVNDPPVPALLWAQEVGQVLAGRARRLLLQFGVLFCTILLLLWVSVFLYGSFYYSYMPTVSHLSPVHFYYRTDCDSSTTSLCSFPVANVSLTKGGRDRVLMYGQPYRVTLELELPESPVNQDLGMFLVTISCYTRGGRIISTSSRSVMLHYRSDLLQMLDTLVFSSLLLFGFAEQKQLLEVELYADYRENSYVPTTGAIIEIHSKRIQLYGAYLRIHAHFTGLRYLLYNFPMTCAFIGVASNFTFLSVIVLFSYMQWVWGGIWPRHRFSLQVNIRKRDNSRKEVQRRISAHQPGPEGQEESTPQSDVTEDGESPEDPSGTEGQLSEEEKPDQQPLSGEEELEPEASDGSGSWEDAALLTEANLPAPAPASASAPVLETLGSSEPAGGALRQRPTCSSS
UniProt
Q96G97
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Variants
Molecule details ›

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