› 6dyr

X-ray diffraction
2.45Å resolution

C-terminal condensation domain of Ebony in complex with Carcinine

Released:
DOI: 10.2210/pdb6dyr/pdb
PDB entry 6dyr coloured by chain, front view.
PDB entry 6dyr coloured by chain, side view.
PDB entry 6dyr coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain.
Izoré T, Tailhades J, Hansen MH, Kaczmarski JA, Jackson CJ, Cryle MJ
Proc Natl Acad Sci U S A 116 2913-2918 (2019)
PMID: 30705105

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-alanyl-bioamine nonribosomal peptide synthetase ebony Chain: A
Molecule details ›
Chain: A
Length: 223 amino acids
Theoretical weight: 25.99 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9VDC6 (Residues: 666-879; Coverage: 24%)
Gene names: CG3331, e

Ligands and Environments

1 bound ligand:
Ligand HJD 1 x HJD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 44.52Å b: 56.05Å c: 49.73Å
α: 90° β: 112.91° γ: 90°
R-values:
R R work R free
0.186 0.184 0.23
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Mining genomes to illuminate the specialized chemistry of life.
Medema et al. (2021)
3 more

1 mention without citation

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain.
Izoré et al. (2019)