› 6e1p

Electron Microscopy
3.7Å resolution

Structure of AtTPC1(DDE) in state 2

Released:
DOI: 10.2210/pdb6e1p/pdb
PDB entry 6e1p coloured by chain, front view.
PDB entry 6e1p coloured by chain, side view.
PDB entry 6e1p coloured by chain, top view.
Source organism: Arabidopsis thaliana
Primary publication:
Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM
Proc Natl Acad Sci U S A 115 E9095-E9104 (2018)
PMID: 30190435
Related structures: EMD-8960

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Two pore calcium channel protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 727 amino acids
Theoretical weight: 84.55 KDa
Source organism: Arabidopsis thaliana
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q94KI8 (Residues: 11-733; Coverage: 99%)
Gene names: At4g03560, CCH1, F9H3.19, FOU2, T5L23.5, TPC1
Sequence domains: Ion transport protein

Ligands and Environments

2 bound ligands:
Ligand CA 5 x CA
Ligand PLM 16 x PLM
2 modified residues:
Ligand SEP 2 x SEP
Ligand TPO 4 x TPO

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-8960
Expression system: Saccharomyces cerevisiae

Quick links

Citations

5 review citations

Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment.
Autzen et al. (2019)
4 more

3 mentions without citation

Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.
Enkavi et al. (2019)
2 more