› 6eaf

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT G143S STABILIZED IN THE PREFUSION STATE

Released:
DOI: 10.2210/pdb6eaf/pdb
PDB entry 6eaf coloured by chain, front view.
PDB entry 6eaf coloured by chain, side view.
PDB entry 6eaf coloured by chain, top view.
Source organism: Human orthopneumovirus
Entry authors: Battles MB, McLellan JS

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fusion glycoprotein F0 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 568 amino acids
Theoretical weight: 63.25 KDa
Source organism: Human orthopneumovirus
Expression system: Homo sapiens
UniProt:
  • Canonical: P03420 (Residues: 1-513; Coverage: 89%)
Gene name: F
Sequence domains: Fusion glycoprotein F0

Ligands and Environments

3 bound ligands:
Ligand NAG 1 x NAG
Ligand SO4 19 x SO4
Ligand NHE 6 x NHE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41212
Unit cell:
a: 167.249Å b: 167.249Å c: 173.309Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.198 0.229
Expression system: Homo sapiens

Quick links