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Crystal structure of Rhodiola rosea 4-hydroxyphenylacetaldehyde synthase

Source organism: Rhodiola rosea
Biochemical function: pyridoxal phosphate binding
Biological process: carboxylic acid metabolic process
Cellular component: cytoplasm

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EC 4.1.1.108: 4-hydroxyphenylacetaldehyde synthase

Reaction catalysed:
L-tyrosine + O(2) + H(2)O = (4-hydroxyphenyl)acetaldehyde + CO(2) + NH(3) + H(2)O(2)
Systematic name:
L-tyrosine carboxy-lyase (oxidative-deaminating)
Alternative Name(s):
  • TYRDC-2 (gene name)

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00282
Domain description: Pyridoxal-dependent decarboxylase conserved domain
Occurring in:
  1. 4-hydroxyphenylacetaldehyde synthase
The deposited structure of PDB entry 6eeq contains 1 copy of Pfam domain PF00282 (Pyridoxal-dependent decarboxylase conserved domain) in 4-hydroxyphenylacetaldehyde synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR010977
Domain description: Aromatic-L-amino-acid decarboxylase
Occurring in:
  1. 4-hydroxyphenylacetaldehyde synthase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. 4-hydroxyphenylacetaldehyde synthase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. 4-hydroxyphenylacetaldehyde synthase
IPR002129
Domain description: Pyridoxal phosphate-dependent decarboxylase
Occurring in:
  1. 4-hydroxyphenylacetaldehyde synthase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. 4-hydroxyphenylacetaldehyde synthase

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