› 6et8

X-ray diffraction
1.7Å resolution

Crystal structure of AlbA in complex with albicidin

Released:
DOI: 10.2210/pdb6et8/pdb
PDB entry 6et8 coloured by chain, front view.
PDB entry 6et8 coloured by chain, side view.
PDB entry 6et8 coloured by chain, top view.
Source organism: Klebsiella oxytoca
Primary publication:
Molecular insights into antibiotic resistance - how a binding protein traps albicidin.
Rostock L, Driller R, Grätz S, Kerwat D, von Eckardstein L, Petras D, Kunert M, Alings C, Schmitt FJ, Friedrich T, Wahl MC, Loll B, Mainz A, Süssmuth RD
OpenAccess logo Nat Commun 9 3095 (2018)
PMID: 30082794

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185211 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TipAS antibiotic-recognition domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 222 amino acids
Theoretical weight: 26.58 KDa
Source organism: Klebsiella oxytoca
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8KRS7 (Residues: 2-221; Coverage: 100%)
Gene name: albA
Sequence domains: TipAS antibiotic-recognition domain

Ligands and Environments

2 bound ligands:
Ligand BWH 2 x BWH
Ligand SO4 1 x SO4
1 modified residue:
Ligand MSE 24 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2221
Unit cell:
a: 54.07Å b: 123.35Å c: 159.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.177 0.204
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Crossroads of Antibiotic Resistance and Biosynthesis.
Wencewicz TA. (2019)
3 more

3 mentions without citation

Molecular insights into antibiotic resistance - how a binding protein traps albicidin.
Rostock et al. (2018)
2 more