6euv

X-ray diffraction
2.7Å resolution

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-151984 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase basic protein 2 Chains: A, C, F, I
Molecule details ›
Chains: A, C, F, I
Length: 290 amino acids
Theoretical weight: 32.52 KDa
Source organism: Influenza A virus (A/Victoria/3/1975(H3N2))
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31345 (Residues: 247-536; Coverage: 38%)
Gene name: PB2
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: P1
Unit cell:
a: 54.49Å b: 80.32Å c: 92.32Å
α: 89.54° β: 107.12° γ: 99.11°
R-values:
R R work R free
0.245 0.243 0.282
Expression system: Escherichia coli BL21(DE3)