6f08

X-ray diffraction
1.9Å resolution

14-3-3 zeta in complex with the human Son of sevenless homolog 1 (SOS1)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-549497 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein zeta/delta Chains: A, B, I, J
Molecule details ›
Chains: A, B, I, J
Length: 230 amino acids
Theoretical weight: 26.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63104 (Residues: 1-230; Coverage: 94%)
Gene name: YWHAZ
Sequence domains: 14-3-3 protein
Structure domains: 14-3-3 domain
Son of sevenless homolog 1 Chains: D, K, N, Q
Molecule details ›
Chains: D, K, N, Q
Length: 13 amino acids
Theoretical weight: 1.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q07889 (Residues: 1155-1167; Coverage: 1%)
Gene name: SOS1

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P21
Unit cell:
a: 67.059Å b: 93.14Å c: 74.519Å
α: 90° β: 92.93° γ: 90°
R-values:
R R work R free
0.213 0.21 0.267
Expression systems:
  • Escherichia coli
  • Not provided