› 6f83

X-ray diffraction
2.2Å resolution

Crystal Structure of Human Galectin-1 in Complex With Thienyl-1,2, 3-triazolyl Thiodigalactoside Inhibitor

Released:
DOI: 10.2210/pdb6f83/pdb
PDB entry 6f83 coloured by chain, front view.
PDB entry 6f83 coloured by chain, side view.
PDB entry 6f83 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Collins PM, Blanchard H

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 134 amino acids
Theoretical weight: 14.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09382 (Residues: 2-135; Coverage: 99%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand 5KT 2 x 5KT
1 modified residue:
Ligand CME 10 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: P212121
Unit cell:
a: 44.447Å b: 58.689Å c: 112.353Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.171 0.224
Expression system: Escherichia coli BL21(DE3)

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