Function and Biology

Crystal structure of P. abyssi Sua5 complexed with L-threonine and PPi

Source organism: Pyrococcus abyssi GE5
Biochemical function: L-threonylcarbamoyladenylate synthase
Biological process: tRNA processing
Cellular component: cytoplasm

EC 2.7.7.87: L-threonylcarbamoyladenylate synthase

Reaction catalysed:
L-threonine + ATP + HCO(3)(-) = L-threonylcarbamoyladenylate + diphosphate + H(2)O
Systematic name:
ATP:L-threonyl,HCO(3)(-) adenylyltransferase
Alternative Name(s):
  • Sua5
  • YrdC (gene name)
  • YwlC (gene name)

Sequence families

Pfam Protein families (Pfam)
PF03481
Domain description: Threonylcarbamoyl-AMP synthase, C-terminal domain
Occurring in:
  1. Threonylcarbamoyl-AMP synthase
The deposited structure of PDB entry 6f87 contains 4 copies of Pfam domain PF03481 (Threonylcarbamoyl-AMP synthase, C-terminal domain) in Threonylcarbamoyl-AMP synthase. Showing 1 copy in chain A.

PF01300
Domain description: Telomere recombination
Occurring in:
  1. Threonylcarbamoyl-AMP synthase
The deposited structure of PDB entry 6f87 contains 4 copies of Pfam domain PF01300 (Telomere recombination) in Threonylcarbamoyl-AMP synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006070
Domain description: Threonylcarbamoyl-AMP synthase-like domain
Occurring in:
  1. Threonylcarbamoyl-AMP synthase
IPR038385
Domain description: Threonylcarbamoyl-AMP synthase, C-terminal domain superfamily
Occurring in:
  1. Threonylcarbamoyl-AMP synthase
IPR005145
Domain description: Threonylcarbamoyl-AMP synthase, C-terminal domain
Occurring in:
  1. Threonylcarbamoyl-AMP synthase
IPR017945
Domain description: DHBP synthase RibB-like alpha/beta domain superfamily
Occurring in:
  1. Threonylcarbamoyl-AMP synthase
IPR010923
Domain description: tRNA threonylcarbamoyladenosine biosynthesis protein SUA5
Occurring in:
  1. Threonylcarbamoyl-AMP synthase