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Antibody derived (Abd-5) small molecule binding to KRAS.

Source organism: Homo sapiens
Biochemical function: GTP binding
Biological process: signal transduction
Cellular component: membrane

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EC 3.6.5.2: Small monomeric GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00071
Domain description: Ras family
Occurring in:
  1. GTPase KRas, N-terminally processed
  2. GTPase KRas, N-terminally processed
  3. GTPase KRas, N-terminally processed
The deposited structure of PDB entry 6fa2 contains 1 copy of Pfam domain PF00071 (Ras family) in GTPase KRas, N-terminally processed. Showing 1 copy in chain A.
The deposited structure of PDB entry 6fa2 contains 4 copies of Pfam domain PF00071 (Ras family) in GTPase KRas, N-terminally processed. Showing 1 copy in chain B.
The deposited structure of PDB entry 6fa2 contains 1 copy of Pfam domain PF00071 (Ras family) in GTPase KRas, N-terminally processed. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR001806
Domain description: Small GTPase
Occurring in:
  1. GTPase KRas, N-terminally processed
  2. GTPase KRas, N-terminally processed
  3. GTPase KRas, N-terminally processed
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. GTPase KRas, N-terminally processed
  2. GTPase KRas, N-terminally processed
  3. GTPase KRas, N-terminally processed
IPR020849
Domain description: Small GTPase, Ras-type
Occurring in:
  1. GTPase KRas, N-terminally processed
  2. GTPase KRas, N-terminally processed
  3. GTPase KRas, N-terminally processed
IPR005225
Domain description: Small GTP-binding domain
Occurring in:
  1. GTPase KRas, N-terminally processed
  2. GTPase KRas, N-terminally processed
  3. GTPase KRas, N-terminally processed

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. GTPase KRas, N-terminally processed
  2. GTPase KRas, N-terminally processed
  3. GTPase KRas, N-terminally processed
The deposited structure of PDB entry 6fa2 contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in GTPase KRas, N-terminally processed. Showing 1 copy in chain A.
The deposited structure of PDB entry 6fa2 contains 4 copies of CATH domain 3.40.50.300 (Rossmann fold) in GTPase KRas, N-terminally processed. Showing 1 copy in chain B.
The deposited structure of PDB entry 6fa2 contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in GTPase KRas, N-terminally processed. Showing 1 copy in chain C.

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