› 6ffk

X-ray diffraction
1.94Å resolution

Human apo-SOD1 bound to PtCl2(1R,2R-1,4-DACH

Released:
DOI: 10.2210/pdb6ffk/pdb
PDB entry 6ffk coloured by chain, front view.
PDB entry 6ffk coloured by chain, side view.
PDB entry 6ffk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interaction of Half Oxa-/Half cis-Platin Complex with Human Superoxide Dismutase and Induced Reduction of Neurotoxicity.
Cantini F, Calderone V, Di Cesare Mannelli L, Korsak M, Gonnelli L, Francesconi O, Ghelardini C, Banci L, Nativi C
ACS Med Chem Lett 9 1094-1098 (2018)
PMID: 30429951

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132494 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B, D, F
Molecule details ›
Chains: A, B, D, F
Length: 153 amino acids
Theoretical weight: 15.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00441 (Residues: 2-154; Coverage: 99%)
Gene name: SOD1
Sequence domains: Copper/zinc superoxide dismutase (SODC)

Ligands and Environments

1 bound ligand:
Ligand D7Z 4 x D7Z
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: C2
Unit cell:
a: 156.85Å b: 35.37Å c: 114.59Å
α: 90° β: 112.26° γ: 90°
R-values:
R R work R free
0.227 0.226 0.256
Expression system: Escherichia coli

Quick links

Citations

1 citations in other articles

Niosomal Formulation of a Lipoyl-Carnosine Derivative Targeting TRPA1 Channels in Brain.
Maestrelli et al. (2019)