› 6fhu

X-ray diffraction
2Å resolution

Crystal structure of BAZ2A PHD zinc finger in complex with H3 3-mer peptide

Released:
DOI: 10.2210/pdb6fhu/pdb
PDB entry 6fhu coloured by chain, front view.
PDB entry 6fhu coloured by chain, side view.
PDB entry 6fhu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.
Amato A, Lucas X, Bortoluzzi A, Wright D, Ciulli A
OpenAccess logo ACS Chem Biol 13 915-921 (2018)
PMID: 29529862

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-166712 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain adjacent to zinc finger domain protein 2A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 58 amino acids
Theoretical weight: 6.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIF9 (Residues: 1673-1728; Coverage: 3%)
Gene names: BAZ2A, KIAA0314, TIP5
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)
ALA-ARG-TAM Chains: F, G, H
Molecule details ›
Chains: F, G, H
Length: 3 amino acids
Theoretical weight: 346 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand ZN 8 x ZN
Ligand PO4 3 x PO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P43212
Unit cell:
a: 73.385Å b: 73.385Å c: 99.671Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.235
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

4 review citations

Targeting epigenetic protein-protein interactions with small-molecule inhibitors.
Linhares et al. (2020)
3 more

1 mention without citation

Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.
Amato et al. (2018)