› 6fhz

X-ray diffraction
2.8Å resolution

Inward-facing conformation of a multidrug resistance MATE family transporter of the MOP superfamily.

Released:
DOI: 10.2210/pdb6fhz/pdb
PDB entry 6fhz coloured by chain, front view.
PDB entry 6fhz coloured by chain, side view.
PDB entry 6fhz coloured by chain, top view.
Source organism: Pyrococcus furiosus DSM 3638
Primary publication:
Inward-facing conformation of a multidrug resistance MATE family transporter.
Zakrzewska S, Mehdipour AR, Malviya VN, Nonaka T, Koepke J, Muenke C, Hausner W, Hummer G, Safarian S, Michel H
Proc Natl Acad Sci U S A 116 12275-12284 (2019)
PMID: 31160466

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186448 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MATE family efflux transporter Chain: A
Molecule details ›
Chain: A
Length: 440 amino acids
Theoretical weight: 47.03 KDa
Source organism: Pyrococcus furiosus DSM 3638
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8U2X0 (Residues: 17-456; Coverage: 95%)
Gene name: PF0708
Sequence domains: MatE

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 107.12Å b: 134.31Å c: 69.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.228 0.274
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Membrane Efflux Pumps of Pathogenic Vibrio Species: Role in Antimicrobial Resistance and Virulence.
Stephen et al. (2022)
3 more

8 mentions without citation

The Bacterial Cell Wall: From Lipid II Flipping to Polymerization.
Kumar et al. (2022)
7 more