› 6fi1

X-ray diffraction
2.7Å resolution

Crystal structure of human BAZ2B PHD zinc finger in complex with Fr23

Released:
DOI: 10.2210/pdb6fi1/pdb
PDB entry 6fi1 coloured by chain, front view.
PDB entry 6fi1 coloured by chain, side view.
PDB entry 6fi1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.
Amato A, Lucas X, Bortoluzzi A, Wright D, Ciulli A
OpenAccess logo ACS Chem Biol 13 915-921 (2018)
PMID: 29529862

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193783 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2B Chains: A, B
Molecule details ›
Chains: A, B
Length: 58 amino acids
Theoretical weight: 6.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIF8 (Residues: 1928-1983; Coverage: 3%)
Gene names: BAZ2B, KIAA1476
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

2 bound ligands:
Ligand ZN 4 x ZN
Ligand D3H 1 x D3H
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 37.779Å b: 45.47Å c: 64.829Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.226 0.3
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

Targeting epigenetic protein-protein interactions with small-molecule inhibitors.
Linhares et al. (2020)
3 more

1 mention without citation

Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.
Amato et al. (2018)