› 6fmc

X-ray diffraction
0.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuropilin-1 Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14786 (Residues: 273-427; Coverage: 17%)
Gene names: NRP, NRP1, VEGF165R
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

1 bound ligand:
Ligand DUE 1 x DUE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P41
Unit cell:
a: 43.44Å b: 43.44Å c: 91.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.11 0.109 0.132
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy.
Henke et al. (2019)
11 more

10 mentions without citation

SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia.
Moutal et al. (2021)
9 more

PDB-REDO

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PDB-REDO