› 6fng

X-ray diffraction
1.04Å resolution

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with an isomer of NVP-BHG712

Released:
DOI: 10.2210/pdb6fng/pdb
PDB entry 6fng coloured by chain, front view.
PDB entry 6fng coloured by chain, side view.
PDB entry 6fng coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
Tröster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Müller S, Kuster B, Médard G, Kudlinzki D, Schwalbe H
ChemMedChem 13 1629-1633 (2018)
PMID: 29928781

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29317 (Residues: 596-900; Coverage: 32%)
Gene names: ECK, EPHA2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand DWT 1 x DWT
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P21
Unit cell:
a: 32.697Å b: 106.926Å c: 40.665Å
α: 90° β: 109.19° γ: 90°
R-values:
R R work R free
0.173 0.175 0.187
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

EphrinB2-EphB4 Signaling in Neurooncological Disease.
Piffko et al. (2022)
1 more

1 mention without citation

Identification of Druggable Kinase Target Conformations Using Markov Model Metastable States Analysis of apo-Abl.
Paul et al. (2020)