6fs6

X-ray diffraction
2.29Å resolution

Influenza A/California/04/2009 (pH1N1) endonuclease with bound inhibitor, baloxavir acid (BXA)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-503966 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polymerase acidic protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 193 amino acids
Theoretical weight: 22.53 KDa
Source organism: Influenza A virus (A/California/04/2009(H1N1))
Expression system: Escherichia coli
UniProt:
  • Canonical: C3W5S0 (Residues: 1-51, 65-198; Coverage: 26%)
Gene name: PA
Structure domains: Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: P21212
Unit cell:
a: 135.18Å b: 75.69Å c: 121.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.231
Expression system: Escherichia coli