› 6g0v

X-ray diffraction
1.09Å resolution

Human Galectin-3 in complex with a TF tumor-associated antigen mimetic

Released:
DOI: 10.2210/pdb6g0v/pdb
PDB entry 6g0v coloured by chain, front view.
PDB entry 6g0v coloured by chain, side view.
PDB entry 6g0v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular Recognition of a Thomsen-Friedenreich Antigen Mimetic Targeting Human Galectin-3.
Santarsia S, Grosso AS, Trovão F, Jiménez-Barbero J, Carvalho AL, Nativi C, Marcelo F
ChemMedChem 13 2030-2036 (2018)
PMID: 30094951

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-3 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17931 (Residues: 114-250; Coverage: 55%)
Gene names: LGALS3, MAC2
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand EGZ 1 x EGZ
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P212121
Unit cell:
a: 35.9Å b: 58.2Å c: 62.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.177
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Glycan structures and their interactions with proteins. A NMR view.
Gimeno et al. (2020)
4 more

1 mention without citation

Computational Study of Potential Galectin-3 Inhibitors in the Treatment of COVID-19.
Aminpour et al. (2021)